Immunofluorescence Examination of Typical Staphylococcus aureus Variants and L-forms for Clumping Factor
نویسندگان
چکیده
منابع مشابه
Immunofluorescence examination of typical Staphylococcus aureus variants and L-forms for clumping factor.
Part I issued January 1970 PAGE Immunofluorescence Examination of Typical Staphylococcus aureus Variants and L-forms for Clumping Factor. By K. L. ELKINS, R. M. HYDE and F. C. KELLY . Basidiospore Germination in the Wood-destroying Fungus Lenzites saepiaria. By H. W. SCHELD and J. J. PERRY Some Properties of the Galactanase Secreted by Phytophthora infestnns (Mont.) De Bary. By M. KNEE and J. F...
متن کاملImmunogenicity analysis of Staphylococcus aureus clumping factor A genetic variants.
The staphylococcal adhesin clumping factor A (ClfA) has a variant amino acid sequence, generating the potential for alterations in epitope structure and immunogenicity of this vaccine candidate. We demonstrated for two recombinant ClfA(40-531) (a slightly truncated version of the fibrinogen-binding domain of ClfA containing amino acids 40 to 531) genetic variants that strain-specific epitopes a...
متن کاملFibrinogen-binding protein/clumping factor from Staphylococcus aureus.
The binding of staphylococcal components to fibrinogen was studied. Fibrinogen-binding material from lysed staphylococcal cells or culture supernatants was affinity purified on fibrinogen-Sepharose and analyzed on Western (immuno-) blots by the use of fibrinogen and antifibrinogen antibodies. Two main bands of 87 and 19 kilodaltons (kDa) and a weaker band of 35 kDa bound specifically to fibrino...
متن کاملStaphylococcus aureus Clumping Factor A Remains a Viable Vaccine Target for Prevention of S. aureus Infection
In a recent article, X. Li et al. [mBio 7(1):e02232-15, 2016, http://dx.doi.org/10.1128/mBio.02232-15] investigate the utility of a vaccine composed of the Staphylococcus aureus protein clumping factor A (ClfA) in protecting mice from S. aureus infection. ClfA, one of the first proteins to be identified as a potential vaccine antigen for S. aureus prophylaxis, is currently a component of severa...
متن کاملFibrinogen Binding Sites P336 and Y338 of Clumping Factor A Are Crucial for Staphylococcus aureus Virulence
We have earlier shown that clumping factor A (ClfA), a fibrinogen binding surface protein of Staphylococcus aureus, is an important virulence factor in septic arthritis. When two amino acids in the ClfA molecule, P(336) and Y(338), were changed to serine and alanine, respectively, the fibrinogen binding property was lost. ClfAP(336)Y(338) mutants have been constructed in two virulent S. aureus ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of General Microbiology
سال: 1970
ISSN: 0022-1287
DOI: 10.1099/00221287-60-1-1